LOCUS NG_011778 10321 bp DNA linear PRI 21-JUN-2009 DEFINITION Homo sapiens insulin-like growth factor binding protein, acid labile subunit (IGFALS) on chromosome 16. ACCESSION NG_011778 VERSION NG_011778.1 GI:226437619 KEYWORDS RefSeqGene. SOURCE Homo sapiens (human) ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC012180.6. Summary: The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq]. PRIMARY REFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-10321 AC012180.6 25424-35744 c FEATURES Location/Qualifiers source 1..10321 /organism="Homo sapiens" /mol_type="genomic DNA" /db_xref="taxon:9606" /chromosome="16" /map="16p13.3" gene 5001..8321 /gene="IGFALS" /gene_synonym="ALS" /note="insulin-like growth factor binding protein, acid labile subunit" /db_xref="GeneID:3483" /db_xref="HGNC:5468" /db_xref="MIM:601489" mRNA join(5001..5097,6333..8321) /gene="IGFALS" /gene_synonym="ALS" /product="insulin-like growth factor binding protein, acid labile subunit" /transcript_id="NM_004970.2" /db_xref="GI:225579150" /db_xref="GeneID:3483" /db_xref="HGNC:5468" /db_xref="MIM:601489" exon 5001..5097 /gene="IGFALS" /gene_synonym="ALS" /inference="alignment:Splign" /number=2 CDS join(5082..5097,6333..8134) /gene="IGFALS" /gene_synonym="ALS" /note="isoform 2 precursor is encoded by transcript variant 2" /codon_start=1 /protein_id="NP_004961.1" /db_xref="GI:4826772" /db_xref="CCDS:CCDS10446.1" /db_xref="GeneID:3483" /db_xref="HGNC:5468" /db_xref="MIM:601489" exon 6333..8321 /gene="IGFALS" /gene_synonym="ALS" /inference="alignment:Splign" /number=3b STS 7558..8332 /standard_name="IGFALS_349" /db_xref="UniSTS:277358" STS 8136..8314 /gene="IGFALS" /gene_synonym="ALS" /standard_name="D16S2960" /db_xref="UniSTS:26794" gene complement(9543..>10321) /gene="NUBP2" /gene_synonym="CFD1; NUBP1" /note="nucleotide binding protein 2 (MinD homolog, E. coli)" /db_xref="GeneID:10101" /db_xref="HGNC:8042" /db_xref="MIM:610779" mRNA complement(9543..>10165) /gene="NUBP2" /gene_synonym="CFD1; NUBP1" /product="nucleotide binding protein 2 (MinD homolog, E. coli)" /transcript_id="NM_012225.2" /db_xref="GI:193083176" /db_xref="GeneID:10101" /db_xref="HGNC:8042" /db_xref="MIM:610779" STS 9583..9727 /standard_name="RH41941" /db_xref="UniSTS:27218" CDS complement(10020..>10165) /gene="NUBP2" /gene_synonym="CFD1; NUBP1" /codon_start=3 /protein_id="NP_036357.1" /db_xref="GI:6912540" /db_xref="CCDS:CCDS10445.1" /db_xref="GeneID:10101" /db_xref="HGNC:8042" /db_xref="MIM:610779" ORIGIN 1 cttctgcctg gacatccagt agttcctata catcctctga aatccaggca gaggttccta 61 aacctgaatt tttaatttat taatttattt atgtttgaga tggcgtcttg ctctgtcacc 121 caggctggag tgcagtggca tgatcttggc tcactgcaac ttctgcctcc caggttcaag 181 tgattctccc acctcagcct cccaggtagc tgggactaga ggcgtgcacc accatgcttg 241 gctaattttt gtatttttag tagggacacg gtttcaccat gttggccagg ctggtctcaa 301 actcctgacc tcaggtgatc cacttgcctc ggcctcccaa agtgttggga ttacaggcgt 361 gagccattgc acctagctcc caaacctcaa ttcttgactt ctgggcatct gcaggcccaa 421 taccacatgg aaactgccaa ggcttggggc ttgcaccctc tgaagcaaca gtctgagctg 481 taccttggct cctttagcca tggctgggag gcagggcacc cgagactaca caaagcagca 541 aggccctggg tctggtccac taaaccattt tttcctccta ggcctcgggg cctgtgatgg 601 gaggggctgc cctgaagacg tctgacatgc cctggagaca ttttccccac tgtcttggtg 661 attaacattt ggctccttgt tatgcaaatt tctgcagcca gcttaaattt ctcctcagaa 721 aatgggcttt tctgttttat ggcatcatca cgctgcaaat ttttcagtct tttatggttg 781 gcttcccttt taaacataag ttccaattcc aaaccatatc tttgtgaata cataaaactg 841 aatgctttta acagcatcca ggtcacattt tgaacagttt gctgcttaga aatttctttc 901 actggctggg cgcagtggct catgcctgta atcccagcac tttgggaggc caaggcgggc 961 agatcacaag gtcaggagat caagacgctc ctggccaaca tggtgagacc ctgtctctac 1021 taaaaataca aaaattagct gggtgtgaca gcgtgcttct gtagttccag ctactcagga 1081 agctgagaca ggagaatcgc ttgaacatgg gaggcagtgg ttgcagtgag ccgagattgc 1141 gccactgcac tccagcctgg gtgacaaagt gagactccat ctcagaaaaa aaaaaaaaaa 1201 tttatttcac tagatgccct aaatcatctc tcacaagttc aaagttccac aaatctctag 1261 agcaggggca acatgccacc agtctctgct aaaacatagc aagagtcacc tttattccag 1321 tttcctacaa gttcctcttc tccgagacca cctcagcctg gactttgttg gccatatcac 1381 tatcaggatt ttggtcaaag gcattcagca agtctaggaa gcgccagact ttcccacatc 1441 ttcctgtcct tttctgagcc ctccaaacgg ttccaacctc tgcctgctac ccagttccaa 1501 agtcacttcc acatttttgg gtatctttac agcagtgtcc cactgtaata ataattatta 1561 cagtaataat ttactgtatt agtcttttct catgctgctg ataaagacat acctgagact 1621 gggtaattta taaaggaaag aggtttaatg gactcacagt tccacatggc tggggaggcc 1681 tcacaatcat ggcggaaggc agagggtctt acacggcggc aggcaagaga gcgtctgcag 1741 gggaactccc atttataaaa ccatcaggtc tcagccaggc gcagtggctc acgcctgtaa 1801 tcccagcact ttgggaggct gaggcgggtg gatcacgagg tcaggagatc gagaccatcg 1861 tggttaacac ggtgaaaccc catctctact gaaaatacaa aaaattagcc gggcgtagtg 1921 gtgggcacct gtagtcccag ctatttggga ggctgaggca ggagaatggc atgaacctgg 1981 aaggtggagc ttgccgtgag ccgagattgt gccactgcac tccagcctgg gagacagagc 2041 aagactccat ctcaaacaaa cacacaaaaa acaaaaacaa ccatcaggtc tcatgagagt 2101 tactaccaca acagtatggg gaaaactgcc ccctgattga gttgtttcca cctgtccctg 2161 cccttgacac atgggaatta ttacagttca aggtgagatt tgggtgggga tgtgaggcca 2221 aaccaaatca tctttgttgt tggtatctga ggaatcaacc tcaacattta agggatatca 2281 tctcaattaa aattaagaac tctcgccggc ccggtggctc acgcttgtaa tcccagagct 2341 ttgggaggcc aaggcaggca aatcacctga ggtcaggagt ttgagaccag cctgactaac 2401 atggagaaac cctgtctcta ctaaaaatac aaaattaggg gctgggcacg gtggctcaca 2461 cctgtaatcc cagcactttg ggaggccgag gccggcaaat cacccgaggt cgggagtttg 2521 agaccagctt ggccaacatg gtgaaaccct gtctctacta aaaatacaaa acattagcca 2581 ggcgtggtgg ctcatgcctg taatcccagc tacttgggag gctgaggcag aagactcgct 2641 tgaacatggg aggtggaggt tgcagtgagc ggagatcaca ccactggact ccagccctgg 2701 taacagactg agactccatc tcaaaaaata aataaataaa ataaaataaa aattagccag 2761 gtgtggtggt tcatgcctat aatcccagct acttgggagg ctgaggcagg agaactgctt 2821 gaacccagga ggcagaggtt gcagtgagct gagatcgcac cattacactc cagcctgggc 2881 aacgagcaaa actccatctc aaaaaaaaaa aaaaaaaaaa aactcaccag aatcctaacg 2941 agaggacaga aaggccacac acctgagtgt gcgtgctgaa tgcttttgtt ttttcttgta 3001 tcttgcaaat cagaaatcag ccagctaact agaaaatcgg caagagaccg aaaccagcag 3061 tggctgaggc cagatgaccc tgtggctgtg tgctggacaa gatgctcggt ctcccaggtg 3121 atggccaccg tccactcgcc actggcctga gtgtagacag gtatgcaccc acaggatgca 3181 gagccacagg gctcggtggc attgctggaa acagtgagaa ggacagggac agatgtattc 3241 caggacgtga cctagacatg gcctcacctc cctcgggtcc tgtcctacag aaagccaggc 3301 cctgtgcggc ctgaagacag gcagaatgcg gctcatggag gagcctggga ggccaccggc 3361 cttgagctgg gagaggccac ggggagtggg gccattgggg gtggcggcag tgatgggggc 3421 ctctggaact caatgggctg aatgtgtgtg taggcctctg cgttaccaca ggaatcaaag 3481 aggcctggag cccccttacg cggctgccgc aaccctggtg aggctctgcc cgcccgcgac 3541 acccggcccc tcccaaagga agagaacagg gacagattct cccttcccac ctggaatgtg 3601 tggggctccc aggtggggtg cgcggcctga cggaggccgg ggcccccacg gggacctctc 3661 ctgagaggag gccgcccggg tctgctggcc tcaggcccca ggcccctgct gagtctgcgt 3721 tttctgctga gtaaacggat cgtgggtctt tctgggtgtg gactttctcc ccgtggatct 3781 ataatttctc agaagaggag ccgagacgcc acctggaaaa tgatcaattc tcgataaagg 3841 gaagacgatg acagtgggcc ggcggcttcc cacagctctg cacggggcct gccaggtgag 3901 gccggagctg aggatggggt agggccctgg aaaactgtgg tctccccgag ccctggctgt 3961 gcccccgcct gcaccccttc cggctgcttc cctgcacact ttcccactgc cgagggactg 4021 gtgggcaggc cccactgaca gccaggggag gggcctgcag ggacctggag gggaggggct 4081 gcacctgctc aggccctggg ggagagagcg actggttggg aagtggtttg agcaggtgga 4141 ggggaaccag gggcctctgg aggcaggtgg agacggagcc caggggtggc cttggacatg 4201 gctgggcaca cattcctgtg gcctctctgc acacaagcgg tgactgtggg gcggccaggc 4261 cctcaccaga gccttggggg acagcaaggg gcaggtgagg cttgtctgag gcacaagacc 4321 tggctcccat ggccaggcca cccccacaca ctccccgagg atggcgcagg gcaaaagcaa 4381 acaggcgcct gcagccctgc caggcattcc tagaagaggc tgggggcggg gcagtggcca 4441 gacaccagcg cccctggggt cacgggagag gcagggtgag cttgggccct ggacagcacc 4501 gtgggcctga agcccaaacg gcagctccca cccaggctgt agggaacccc cgggagggcg 4561 ggtggatggc tgggtggggc acggggaagg ggcggcagcc ccttagcccc acacggctgg 4621 ctactcaggc caggggtggg ctcaagaccc caggagctgc ccgaggagcc ccctgcccgc 4681 aacaggacct ggtaaaaccc tgggctcccc aaaccggcct caagccccag cccctcccag 4741 gctgctgcaa ggggtcccca ccccaacctg gctgcccagc cctccccagt cagccctgca 4801 gggggcccgg gcactggccg tcagccccca gggccgcatt acggctacct cgggccccga 4861 ctgaagctcc ctcaccccct gcactgtctg caccccaggg ctccgggctg atgccggccg 4921 cccggcacga gggggttaac agagccaggg ccagctgggt tgggccagcc aggtgacagg 4981 cgcgggctgc cccgcagtgg ggaaatccag agggcagggg tggccggcac agcagacgta 5041 ccctccctcg ctgcctgcct gcagcctgcc ctgcatgcag gatggccctg aggaaaggtg 5101 aggcccccga gtgccccgcc acccactcta ggggtggcca gtctgtgacc ctgagcccgc 5161 tggggagagg ccggggtagc ccccaaggaa gctctggggg gctcagctct gggggtctgc 5221 gggggactct ggggagccca cagtcggaaa tgcggctgct ggggttggca gggggacaca 5281 gctgtgcctg gcaccagggg tctctgtccc gtcctccacc ctaagggcgc tggcggcggc 5341 acaggggagg agggccaggt gcaggccgga cccttcagct cccagcacag cggcgggaag 5401 tgccccgcac ggcccgcgtt gtgggcccgg cccaggcagg agacgttggc tcacacccca 5461 ttgtctctgt ggggtgaccc cttgcagctt cggccacccc caagcctgag ctgagctcca 5521 gagctggctc aggccactcc caacccatcg tgacagaagg gcagtcgggg gggccccacc 5581 tcgcccctgc caccatccca gcaattccac actctctgag gatggggggg ccatacagta 5641 gaggttttgg gtcatcgctg cttgggagcc tgctggctgg gtctgtgggg cctgtggccc 5701 cttgtcctga aaggcaatgt gagctttggt ggccgacggt ccagggttcc tacctgtccc 5761 ccgacggcgg tgccccggtc ccctcccgca gcacccgacc aaggcctgga tgcaggcagg 5821 tgagaccccg ctggggggcc taactggggc aggaggtgcc cagctccctg tccagcctct 5881 gagggcagtg agcgagtgcc caccaagacc tgctgcagaa tattctgaaa atggccggac 5941 cttggccaat ggctcagttc cctccccttc ctctaggcca acgtggcaga ctggcctggc 6001 tcaagcgcct gccttggggg tgcggctgcc acatggccag acagcccgag acccagcctg 6061 gccgagccca cgtggcctgc gcacagctgg agagccaagc cctgagcgtc tgtgcagcgg 6121 ggcggggcgg ccactcctct gtcccatggg gtgggaagcg cagtgtcagc ttttgagccg 6181 gaggacctgt ggggctcacc ggcttcttcg catctcagcg ggtgacctcg agcctcagtt 6241 cacacctgag cgccgcttcc ggctgtgctg gtatcaggct cactcgggca gagccctcct 6301 cgggccgcct ccccaagcct ctccccccgc aggaggcctg gccctggcgc tgctgctgct 6361 gtcctgggtg gcactgggcc cccgcagcct ggagggagca gaccccggaa cgccggggga 6421 agccgagggc ccagcgtgcc cggccgcctg tgtctgcagc tacgatgacg acgcggatga 6481 gctcagcgtc ttctgcagct ccaggaacct cacgcgcctg cctgatggag tcccgggcgg 6541 cacccaagcc ctgtggctgg acggcaacaa cctctcgtcc gtccccccgg cagccttcca 6601 gaacctctcc agcctgggct tcctcaacct gcagggcggc cagctgggca gcctggagcc 6661 acaggcgctg ctgggcctag agaacctgtg ccacctgcac ctggagcgga accagctgcg 6721 cagcctggca ctcggcacgt ttgcacacac gcccgcgctg gcctcgctcg gcctcagcaa 6781 caaccgtctg agcaggctgg aggacgggct cttcgagggc ctcggcagcc tctgggacct 6841 caacctcggc tggaatagcc tggcggtgct ccccgatgcg gcgttccgcg gcctgggcag 6901 cctgcgcgag ctggtgctgg cgggcaacag gctggcctac ctgcagcccg cgctcttcag 6961 cggcctggcc gagctccggg agctggacct gagcaggaac gcgctgcggg ccatcaaggc 7021 aaacgtgttc gtgcagctgc cccggctcca gaaactctac ctggaccgca acctcatcgc 7081 tgccgtggcc ccgggcgcct tcctgggcct gaaggcgctg cgatggctgg acctgtccca 7141 caaccgcgtg gctggcctcc tggaggacac gttccccggt ctgctgggcc tgcgtgtgct 7201 gcggctgtcc cacaacgcca tcgccagcct gcggccccgc accttcaagg acctgcactt 7261 cctggaggag ctgcagctgg gccacaaccg catccggcag ctggctgagc gcagctttga 7321 gggcctgggg cagcttgagg tgctcacgct agaccacaac cagctccagg aggtcaaggc 7381 gggcgctttc ctcggcctca ccaacgtggc ggtcatgaac ctctctggga actgtctccg 7441 gaaccttccg gagcaggtgt tccggggcct gggcaagctg cacagcctgc acctggaggg 7501 cagctgcctg ggacgcatcc gcccgcacac cttcaccggc ctctcggggc tccgccgact 7561 cttcctcaag gacaacggcc tcgtgggcat tgaggagcag agcctgtggg ggctggcgga 7621 gctgctggag ctcgacctga cctccaacca gctcacgcac ctgccccacc gcctcttcca 7681 gggcctgggc aagctggagt acctgctgct ctcccgcaac cgcctggcag agctgccggc 7741 ggacgccctg ggccccctgc agcgggcctt ctggctggac gtctcgcaca accgcctgga 7801 ggcattgccc aacagcctct tggcaccact ggggcggctg cgctacctca gcctcaggaa 7861 caactcactg cggaccttca cgccgcagcc cccgggcctg gagcgcctgt ggctggaggg 7921 taacccctgg gactgtggct gccctctcaa ggcgctgcgg gacttcgccc tgcagaaccc 7981 cagtgctgtg ccccgcttcg tccaggccat ctgtgagggg gacgattgcc agccgcccgc 8041 gtacacctac aacaacatca cctgtgccag cccgcccgag gtcgtggggc tcgacctgcg 8101 ggacctcagc gaggcccact ttgctccctg ctgaccaggt ccccggactc aagccccgga 8161 ctcaggcccc cacctggctc accttgtgct ggggacaggt cctcagtgtc ctcaggggcc 8221 tgcccagtgc acttgctgga agacgcaagg gcctgatggg gtggaaggca tggcggcccc 8281 cccagctgtc atcaattaaa ggcaaaggca atcgaatcta acaggcacag tgggtgactg 8341 cgaacgtgaa accagggagg gggctggggg ctcggcgcgc agctgtggtc tcagagcttt 8401 gggaggccga ggcgggcgga tcgcttgagc ccaggagttt gagagaccgt cctgggcaac 8461 acaagagaga ccccgtctct acaaaaaata aaaaaaatta gcatagcatg gtggcccatg 8521 cctgtggtcc tagggaggcc gaggcaggag gactactgga gcctgggagg tagaggctgc 8581 cgtgagccaa gactgcacca ctgcactcca gcctgggcgg cagagcaaca ccctgtctca 8641 aaaaaaccca cctggctcag gggaggggag gatggtgttg cctgggtacg ccttggtctc 8701 ctcacctctc tcctccccgg cttggccacg cccagggccc ccgcctggat cctgccccgc 8761 caccgccctg gccaactgcc ccacacccat gtgtcttcct ggtccccgtg gctgcccctc 8821 gggctcccca gaacatcctc caggaatgat ggcaccaact cgaatcccca ggggctctgc 8881 gtctcacccc tcctctttga gggatcgccc tgaggaccag gcagtgtccc cgaggggtgt 8941 ggtccaggca gccagggcgc ggctgaggtg gggtgaggag ggagcgcggg gcgggccgtc 9001 cgccttgcgt gggaagccgc accccctgca gatgccgtgg gcgtttgtct ctgccccccc 9061 caggcaccgg catcgtcagc ccaggtgctc ctggtgccct ctcacccacc cagaggccgc 9121 ccgggttggt tccgggcccc cacctccagg gtcctcccct gctgaaggct gagctcttcc 9181 tttgggaaaa atggcgcgtt ctgctttctg gaagggcttt cctttcgggt ctcactggga 9241 agaggtgcag gggacccctg ggattggagc tcccttctca acctgacttc tggtctctgt 9301 cccgggaggg gcccctttag tgtcccaggg aggccattct tccacggcga aggggccagc 9361 tgtcaggttt atcacaaaat ctccccgaat tcccaccaaa taagatgcaa acacatcagc 9421 acctgggccc aggggcttgt tgacaacgga acgaacgaac ctgccggcct ggcccagtcc 9481 agcccagaaa cttacagaag caggtgctgt ctgaccccga aggacagaag actctagaaa 9541 catcagatct gtcgccacag cagcggacac gtttaatggc aggcgcctct acagttacaa 9601 aacatgcctg aggtcagttc gcccccttag ggggcactcc ccgagctaaa cacagatgac 9661 agcgacccag ggtgctggag gcccggggtc acctgaggac tgcagaagtc ccgcgctccg 9721 ctaactgtgt ggacacgcgg ctgccagggg cacaggtagg caacatggat gggaagagag 9781 cccaggccgc ccccgtctca cagctgcaga gcacgcagac cacggcactg caggccaacc 9841 aggcagagct gctggtgcga cacatcctgg ggctgggctg gtcggggaga agctctccgg 9901 ctgacgctgc ctgggcctgc ccctgcaggg cccgggaacc gagcccaggc ctctgtttct 9961 ctgagaggct ggagcagagc ccttggtggc cctggaaagc ggctgcaagg tggccttagt 10021 caggggaggc acgcgggcgt cgcgtccaga atcttctggg ctatggaggt gagtgcagcg 10081 aaggcggggc tcccagggaa ctcctggatg aagtcgtggc cctcctccag ggtcctcatg 10141 agcgcagggt ccaggggcac ggagcctgca gggcacagtg gaggcggtgg cgccatgtcc 10201 gcaccttcca ctcccaccat tggctcagct ggacgcaccc gaaccacccg tggccttaga 10261 ggggattgag gcgctgccag acgatttcca cctccagacc cgcggccctc ccagcaggct 10321 g //