IGF1 homepage - LOVD - Leiden Open Variation Database

This database has been established by the Growth Consortium. The variants we have collected can be visualised without registration, just follow the links on these pages (for an explanation regarding all possibilities see Documentation). Note that the database contains much more information (esp. regarding the phenotype) then displayed. Part of this non-public data can be queried, retrieving the number of records fulfilling your query (see Search through hidden entries and Documentation). To get actual access to the non-public data you have to contact the curator(s).
When you study the genes we cover, please consider to become an active collaborator, register as submitter, login and submit the patients/variants you have studied. Note that these databases have most value when really ALL variants are reported.

General information
Gene name	Insulin-like Growth Factor 1
Gene symbol	IGF1
Chromosome Location	12q22-q23
Database location	chromium.liacs.nl
Curator	Jan Maarten Wit and Marie-Jose Walenkamp
PubMed references	View all (unique) PubMed references in the IGF1 database
Date of creation	June 01, 2008
Last update	September 06, 2009
Version	IGF1 090906
Add sequence variant	Submit a sequence variant
First time submitters	Register here
Reference sequence file	coding DNA reference sequence for describing sequence variants
GenBank reference	IGF1_NG011713.1.gb
Exon/intron information	Exon/intron information table
Total number of unique DNA variants reported	3
Total number of individuals with variant(s)	3
Total number of variants reported	6
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Graphical displays and utilities
Summary tables	Summary of all sequence variants in the IGF1 database, sorted by type of variant (with graphical displays and statistics)
Reading-frame checker	The Reading-frame checker generates a prediction of the effect of whole-exon changes

Sequence variant tables
Unique sequence variants	Listing of all unique sequence variants in the IGF1 database, without patient data
Complete sequence variant listing	Listing of all sequence variants in the IGF1 database
Variants with no known pathogenicity	Listing of all IGF1 variants reported to have no noticeable phenotypic effect (note: excluding variants of unknown effect)

Search the database
By type of variant	View all sequence variants of a certain type
Simple search	Query the database by selecting the most important variables (exon number, type of variant, disease phenotype)
Advanced search	Query the database by selecting a combination of variables
Based on patient origin	View all variants based on your patient origin search terms

Links to other resources
External link #1	Orphanet
External link #2	Growth Consortium
HGNC	5464
Entrez Gene	3479
OMIM - Gene	147440
OMIM - Disease	insulin-like growth factor-1 deficiency (IGF-1d)
HGMD	IGF1
GeneTests	IGF1

The contents of this LOVD database are the intellectual property of the respective curator(s). Any unauthorised use, copying, storage or distribution of this material without written permission from the curator(s) will lead to copyright infringement with possible ensuing litigation. Copyright © 2012. All Rights Reserved. For further details, refer to Directive 96/9/EC of the European Parliament and the Council of March 11 (1996) on the legal protection of databases.

We have used all reasonable efforts to ensure that the information displayed on these pages and contained in the databases is of high quality. We make no warranty, express or implied, as to its accuracy or that the information is fit for a particular purpose, and will not be held responsible for any consequences arising out of any inaccuracies or omissions. Individuals, organisations and companies which use this database do so on the understanding that no liability whatsoever either direct or indirect shall rest upon the curator(s) or any of their employees or agents for the effects of any product, process or method that may be produced or adopted by any part, notwithstanding that the formulation of such product, process or method may be based upon information here provided.

LOVD - Leiden Open Variation Database

Insulin-like Growth Factor 1 (IGF1)