Ataxia Telangiectasia Mutated (ATM) - coding DNA reference sequence

(used for mutation description)

(last modified August 3, 2006)


The ATM coding DNA reference sequence is based on U82828; two transcripts have been reported one starting in exon 1a (NM_000051.3) and in in exon 1b (located in intron 1). The ATM gene is 5' directly flanked by the NPAT gene (nuclear protein ataxia-telangiectasia locus, GenBank NM_002519.1).

Please note that introns are available by clicking on the exon numbers above the sequence.


 (upstream sequence)
                                  exon 1a.         .         
                                  agtgggcgctgggcagtcacgcagggt       -301

 .         .         .         .         .         .         
 ttgaaccggaagcgggagtaggtagctgcgtggctaacggagaaaagaagccgtggccac       -241

 .         .         .         .         .         .         
 gggaggaggcgagaggagtcgggatctgcgctgcagccaccgccgcggttgatactactt       -181

 .         .         | 2.         .         .         .         
 tgaccttccgagtgcagtg | gcactgtaagcatgtatatgggtccttaaagggactcatag    -121

 .  | 3       .         .         .         .         .         
 ag | aggcatacatcacaatttggaattatgcattggtttatcaatttacttgtttattgtc    -61

 .         .         .          | 4         .         .         
 accctgctgcccagatatgacttcatgagg | acagtgatgtgtgttctgaaattgtgaacc    -1

          .         .         .         .         .         .
 ATGAGTCTAGTACTTAATGATCTGCTTATCTGCTGCCGTCAACTAGAACATGATAGAGCT        60
 M  S  L  V  L  N  D  L  L  I  C  C  R  Q  L  E  H  D  R  A          20

          .   | 5      .         .         .         .         .
 ACAGAACGAAAG | AAAGAAGTTGAGAAATTTAAGCGCCTGATTCGAGATCCTGAAACAATT     120
 T  E  R  K   | K  E  V  E  K  F  K  R  L  I  R  D  P  E  T  I       40

          .         .         .         .         .         .
 AAACATCTAGATCGGCATTCAGATTCCAAACAAGGAAAATATTTGAATTGGGATGCTGTT        180
 K  H  L  D  R  H  S  D  S  K  Q  G  K  Y  L  N  W  D  A  V          60

       | 6   .         .         .         .         .         .
 TTTAG | ATTTTTACAGAAATATATTCAGAAAGAAACAGAATGTCTGAGAATAGCAAAACCA     240
 F  R  |  F  L  Q  K  Y  I  Q  K  E  T  E  C  L  R  I  A  K  P       80

          .         .         .         .         .         .
 AATGTATCAGCCTCAACACAAGCCTCCAGGCAGAAAAAGATGCAGGAAATCAGTAGTTTG        300
 N  V  S  A  S  T  Q  A  S  R  Q  K  K  M  Q  E  I  S  S  L          100

          .         .         .  | 7       .         .         .
 GTCAAATACTTCATCAAATGTGCAAACAGAA | GAGCACCTAGGCTAAAATGTCAAGAACTC     360
 V  K  Y  F  I  K  C  A  N  R  R |   A  P  R  L  K  C  Q  E  L       120

          .         .         .         .         .         .
 TTAAATTATATCATGGATACAGTGAAAGATTCATCTAATGGTGCTATTTACGGAGCTGAT        420
 L  N  Y  I  M  D  T  V  K  D  S  S  N  G  A  I  Y  G  A  D          140

          .         .         .         .         .         .
 TGTAGCAACATACTACTCAAAGACATTCTTTCTGTGAGAAAATACTGGTGTGAAATATCT        480
 C  S  N  I  L  L  K  D  I  L  S  V  R  K  Y  W  C  E  I  S          160

          .       | 8  .         .         .         .         .
 CAGCAACAGTGGTTAG | AATTGTTCTCTGTGTACTTCAGGCTCTATCTGAAACCTTCACAA     540
 Q  Q  Q  W  L  E |   L  F  S  V  Y  F  R  L  Y  L  K  P  S  Q       180

          .         .         .         .         .         .
 GATGTTCATAGAGTTTTAGTGGCTAGAATAATTCATGCTGTTACCAAAGGATGCTGTTCT        600
 D  V  H  R  V  L  V  A  R  I  I  H  A  V  T  K  G  C  C  S          200

          .         .         .         .         .         .
 CAGACTGACGGATTAAATTCCAAATTTTTGGACTTTTTTTCCAAGGCTATTCAGTGTGCG        660
 Q  T  D  G  L  N  S  K  F  L  D  F  F  S  K  A  I  Q  C  A          220

    | 9      .         .         .         .         .         .
 AG | ACAAGAAAAGAGCTCTTCAGGTCTAAATCATATCTTAGCAGCTCTTACTATCTTCCTC     720
 R  |  Q  E  K  S  S  S  G  L  N  H  I  L  A  A  L  T  I  F  L       240

          .         .         .         .         .         .
 AAGACTTTGGCTGTCAACTTTCGAATTCGAGTGTGTGAATTAGGAGATGAAATTCTTCCC        780
 K  T  L  A  V  N  F  R  I  R  V  C  E  L  G  D  E  I  L  P          260

          .         .         .         .         .         .
 ACTTTGCTTTATATTTGGACTCAACATAGGCTTAATGATTCTTTAAAAGAAGTCATTATT        840
 T  L  L  Y  I  W  T  Q  H  R  L  N  D  S  L  K  E  V  I  I          280

          .         .         .         .         .         .
 GAATTATTTCAACTGCAAATTTATATCCATCATCCGAAAGGAGCCAAAACCCAAGAAAAA        900
 E  L  F  Q  L  Q  I  Y  I  H  H  P  K  G  A  K  T  Q  E  K          300

   | 10      .         .         .         .         .         .
 G | GTGCTTATGAATCAACAAAATGGAGAAGTATTTTATACAACTTATATGATCTGCTAGTG     960
 G |   A  Y  E  S  T  K  W  R  S  I  L  Y  N  L  Y  D  L  L  V       320

          .         .         .         .         .         .
 AATGAGATAAGTCATATAGGAAGTAGAGGAAAGTATTCTTCAGGATTTCGTAATATTGCC        1020
 N  E  I  S  H  I  G  S  R  G  K  Y  S  S  G  F  R  N  I  A          340

          .         .         .         .      | 11  .         .
 GTCAAAGAAAATTTGATTGAATTGATGGCAGATATCTGTCACCAG | GTTTTTAATGAAGAT     1080
 V  K  E  N  L  I  E  L  M  A  D  I  C  H  Q   | V  F  N  E  D       360

          .         .         .         .         .         .
 ACCAGATCCTTGGAGATTTCTCAATCTTACACTACTACACAAAGAGAATCTAGTGATTAC        1140
 T  R  S  L  E  I  S  Q  S  Y  T  T  T  Q  R  E  S  S  D  Y          380

          .         .         .         .         .         .
 AGTGTCCCTTGCAAAAGGAAGAAAATAGAACTAGGCTGGGAAGTAATAAAAGATCACCTT        1200
 S  V  P  C  K  R  K  K  I  E  L  G  W  E  V  I  K  D  H  L          400

          .         .         .      | 12  .         .         .
 CAGAAGTCACAGAATGATTTTGATCTTGTGCCTTG | GCTACAGATTGCAACCCAATTAATA     1260
 Q  K  S  Q  N  D  F  D  L  V  P  W  |  L  Q  I  A  T  Q  L  I       420

          .         .         .         .         .         .
 TCAAAGTATCCTGCAAGTTTACCTAACTGTGAGCTGTCTCCATTACTGATGATACTATCT        1320
 S  K  Y  P  A  S  L  P  N  C  E  L  S  P  L  L  M  I  L  S          440

          .         .         .         .         .         .
 CAGCTTCTACCCCAACAGCGACATGGGGAACGTACACCATATGTGTTACGATGCCTTACG        1380
 Q  L  L  P  Q  Q  R  H  G  E  R  T  P  Y  V  L  R  C  L  T          460

          .         .         .         .         .         .
 GAAGTTGCATTGTGTCAAGACAAGAGGTCAAACCTAGAAAGCTCACAAAAGTCAGATTTA        1440
 E  V  A  L  C  Q  D  K  R  S  N  L  E  S  S  Q  K  S  D  L          480

          .         .         .         .         .         .
 TTAAAACTCTGGAATAAAATTTGGTGTATTACCTTTCGTGGTATAAGTTCTGAGCAAATA        1500
 L  K  L  W  N  K  I  W  C  I  T  F  R  G  I  S  S  E  Q  I          500

          .         .         .         .         .         .
 CAAGCTGAAAACTTTGGCTTACTTGGAGCCATAATTCAGGGTAGTTTAGTTGAGGTTGAC        1560
 Q  A  E  N  F  G  L  L  G  A  I  I  Q  G  S  L  V  E  V  D          520

          .         .         .         .        | 13.         .
 AGAGAATTCTGGAAGTTATTTACTGGGTCAGCCTGCAGACCTTCATG | TCCTGCAGTATGC     1620
 R  E  F  W  K  L  F  T  G  S  A  C  R  P  S  C  |  P  A  V  C       540

          .         .         .         .         .         .
 TGTTTGACTTTGGCACTGACCACCAGTATAGTTCCAGGAACGGTAAAAATGGGAATAGAG        1680
 C  L  T  L  A  L  T  T  S  I  V  P  G  T  V  K  M  G  I  E          560

          .         .         .         .         .         .
 CAAAATATGTGTGAAGTAAATAGAAGCTTTTCTTTAAAGGAATCAATAATGAAATGGCTC        1740
 Q  N  M  C  E  V  N  R  S  F  S  L  K  E  S  I  M  K  W  L          580

          .         .         .         .         .         .
 TTATTCTATCAGTTAGAGGGTGACTTAGAAAATAGCACAGAAGTGCCTCCAATTCTTCAC        1800
 L  F  Y  Q  L  E  G  D  L  E  N  S  T  E  V  P  P  I  L  H          600

    | 14     .         .         .         .         .         .
 AG | TAATTTTCCTCATCTTGTACTGGAGAAAATTCTTGTGAGTCTCACTATGAAAAACTGT     1860
 S  |  N  F  P  H  L  V  L  E  K  I  L  V  S  L  T  M  K  N  C       620

          .         .         .         | 15         .         .
 AAAGCTGCAATGAATTTTTTCCAAAGCGTGCCAGAATG | TGAACACCACCAAAAAGATAAA     1920
 K  A  A  M  N  F  F  Q  S  V  P  E  C  |  E  H  H  Q  K  D  K       640

          .         .         .         .         .         .
 GAAGAACTTTCATTCTCAGAAGTAGAAGAACTATTTCTTCAGACAACTTTTGACAAGATG        1980
 E  E  L  S  F  S  E  V  E  E  L  F  L  Q  T  T  F  D  K  M          660

          .         .         .         .         .         .
 GACTTTTTAACCATTGTGAGAGAATGTGGTATAGAAAAGCACCAGTCCAGTATTGGCTTC        2040
 D  F  L  T  I  V  R  E  C  G  I  E  K  H  Q  S  S  I  G  F          680

          .         .         .         .         .         .
 TCTGTCCACCAGAATCTCAAGGAATCACTGGATCGCTGTCTTCTGGGATTATCAGAACAG        2100
 S  V  H  Q  N  L  K  E  S  L  D  R  C  L  L  G  L  S  E  Q          700

          .         .     | 16   .         .         .         .
 CTTCTGAATAATTACTCATCTGAG | ATTACAAATTCAGAAACTCTTGTCCGGTGTTCACGT     2160
 L  L  N  N  Y  S  S  E   | I  T  N  S  E  T  L  V  R  C  S  R       720

          .         .         .         .         .         .
 CTTTTGGTGGGTGTCCTTGGCTGCTACTGTTACATGGGTGTAATAGCTGAAGAGGAAGCA        2220
 L  L  V  G  V  L  G  C  Y  C  Y  M  G  V  I  A  E  E  E  A          740

          .         .         . | 17       .         .         .
 TATAAGTCAGAATTATTCCAGAAAGCCAAG | TCTCTAATGCAATGTGCAGGAGAAAGTATC     2280
 Y  K  S  E  L  F  Q  K  A  K   | S  L  M  Q  C  A  G  E  S  I       760

          .         .         .         .         .         .
 ACTCTGTTTAAAAATAAGACAAATGAGGAATTCAGAATTGGTTCCTTGAGAAATATGATG        2340
 T  L  F  K  N  K  T  N  E  E  F  R  I  G  S  L  R  N  M  M          780

          .         .         .       | 18 .         .         .
 CAGCTATGTACACGTTGCTTGAGCAACTGTACCAAG | AAGAGTCCAAATAAGATTGCATCT     2400
 Q  L  C  T  R  C  L  S  N  C  T  K   | K  S  P  N  K  I  A  S       800

          .         .         .         .         .         .
 GGCTTTTTCCTGCGATTGTTAACATCAAAGCTAATGAATGACATTGCAGATATTTGTAAA        2460
 G  F  F  L  R  L  L  T  S  K  L  M  N  D  I  A  D  I  C  K          820

        | 19 .         .         .         .         .         .
 AGTTTA | GCATCCTTCATCAAAAAGCCATTTGACCGTGGAGAAGTAGAATCAATGGAAGAT     2520
 S  L   | A  S  F  I  K  K  P  F  D  R  G  E  V  E  S  M  E  D       840

          .         .         .         .         .         .
 GATACTAATGGAAATCTAATGGAGGTGGAGGATCAGTCATCCATGAATCTATTTAACGAT        2580
 D  T  N  G  N  L  M  E  V  E  D  Q  S  S  M  N  L  F  N  D          860

          .         .         .         .         .         | 20
 TACCCTGATAGTAGTGTTAGTGATGCAAACGAACCTGGAGAGAGCCAAAGTACCATAG | GT     2640
 Y  P  D  S  S  V  S  D  A  N  E  P  G  E  S  Q  S  T  I  G |        880

          .         .         .         .         .         .
 GCCATTAATCCTTTAGCTGAAGAATATCTGTCAAAGCAAGATCTACTTTTCTTAGACATG        2700
 A  I  N  P  L  A  E  E  Y  L  S  K  Q  D  L  L  F  L  D  M          900

          .         .         .         .         .         .
 CTCAAGTTCTTGTGTTTGTGTGTAACTACTGCTCAGACCAATACTGTGTCCTTTAGGGCA        2760
 L  K  F  L  C  L  C  V  T  T  A  Q  T  N  T  V  S  F  R  A          920

          .         .         .         .         .         .
 GCTGATATTCGGAGGAAATTGTTAATGTTAATTGATTCTAGCACGCTAGAACCTACCAAA        2820
 A  D  I  R  R  K  L  L  M  L  I  D  S  S  T  L  E  P  T  K          940

          .         | 21         .         .         .         .
 TCCCTCCACCTGCATATG | TATCTAATGCTTTTAAAGGAGCTTCCTGGAGAAGAGTACCCC     2880
 S  L  H  L  H  M   | Y  L  M  L  L  K  E  L  P  G  E  E  Y  P       960

          .         .         .         .  | 22      .         .
 TTGCCAATGGAAGATGTTCTTGAACTTCTGAAACCACTATC | CAATGTGTGTTCTTTGTAT     2940
 L  P  M  E  D  V  L  E  L  L  K  P  L  S  |  N  V  C  S  L  Y       980

          .         .         .         .         .         .
 CGTCGTGACCAAGATGTTTGTAAAACTATTTTAAACCATGTCCTTCATGTAGTGAAAAAC        3000
 R  R  D  Q  D  V  C  K  T  I  L  N  H  V  L  H  V  V  K  N          1000

          .         .         .         .         .         .
 CTAGGTCAAAGCAATATGGACTCTGAGAACACAAGGGATGCTCAAGGACAGTTTCTTACA        3060
 L  G  Q  S  N  M  D  S  E  N  T  R  D  A  Q  G  Q  F  L  T          1020

          .        | 23.         .         .         .         .
 GTAATTGGAGCATTTTG | GCATCTAACAAAGGAGAGGAAATATATATTCTCTGTAAGAATG     3120
 V  I  G  A  F  W  |  H  L  T  K  E  R  K  Y  I  F  S  V  R  M       1040

          .         .         .    | 24    .         .         .
 GCCCTAGTAAATTGCCTTAAAACTTTGCTTGAG | GCTGATCCTTATTCAAAATGGGCCATT     3180
 A  L  V  N  C  L  K  T  L  L  E   | A  D  P  Y  S  K  W  A  I       1060

          .         .         .         .         .         .
 CTTAATGTAATGGGAAAAGACTTTCCTGTAAATGAAGTATTTACACAATTTCTTGCTGAC        3240
 L  N  V  M  G  K  D  F  P  V  N  E  V  F  T  Q  F  L  A  D          1080

          .         .         .         .     | 25   .         .
 AATCATCACCAAGTTCGCATGTTGGCTGCAGAGTCAATCAATAG | ATTGTTCCAGGACACG     3300
 N  H  H  Q  V  R  M  L  A  A  E  S  I  N  R  |  L  F  Q  D  T       1100

          .         .         .         .         .         .
 AAGGGAGATTCTTCCAGGTTACTGAAAGCACTTCCTTTGAAGCTTCAGCAAACAGCTTTT        3360
 K  G  D  S  S  R  L  L  K  A  L  P  L  K  L  Q  Q  T  A  F          1120

          .         .         .         .   | 26     .         .
 GAAAATGCATACTTGAAAGCTCAGGAAGGAATGAGAGAAATG | TCCCATAGTGCTGAGAAC     3420
 E  N  A  Y  L  K  A  Q  E  G  M  R  E  M   | S  H  S  A  E  N       1140

          .         .         .         .         .         .
 CCTGAAACTTTGGATGAAATTTATAATAGAAAATCTGTTTTACTGACGTTGATAGCTGTG        3480
 P  E  T  L  D  E  I  Y  N  R  K  S  V  L  L  T  L  I  A  V          1160

          .         .         .         .         .         .
 GTTTTATCCTGTAGCCCTATCTGCGAAAAACAGGCTTTGTTTGCCCTGTGTAAATCTGTG        3540
 V  L  S  C  S  P  I  C  E  K  Q  A  L  F  A  L  C  K  S  V          1180

          .         .         .       | 27 .         .         .
 AAAGAGAATGGATTAGAACCTCACCTTGTGAAAAAG | GTTTTAGAGAAAGTTTCTGAAACT     3600
 K  E  N  G  L  E  P  H  L  V  K  K   | V  L  E  K  V  S  E  T       1200

          .         .         .         .         .         .
 TTTGGATATAGACGTTTAGAAGACTTTATGGCATCTCATTTAGATTATCTGGTTTTGGAA        3660
 F  G  Y  R  R  L  E  D  F  M  A  S  H  L  D  Y  L  V  L  E          1220

          .         .         .         .         .         .
 TGGCTAAATCTTCAAGATACTGAATACAACTTATCTTCTTTTCCTTTTATTTTATTAAAC        3720
 W  L  N  L  Q  D  T  E  Y  N  L  S  S  F  P  F  I  L  L  N          1240

          .         .       | 28 .         .         .         .
 TACACAAATATTGAGGATTTCTATAG | ATCTTGTTATAAGGTTTTGATTCCACATCTGGTG     3780
 Y  T  N  I  E  D  F  Y  R  |  S  C  Y  K  V  L  I  P  H  L  V       1260

          .         .         .         .         .         .
 ATTAGAAGTCATTTTGATGAGGTGAAGTCCATTGCTAATCAGATTCAAGAGGACTGGAAA        3840
 I  R  S  H  F  D  E  V  K  S  I  A  N  Q  I  Q  E  D  W  K          1280

          .         .         .         .         .         .
 AGTCTTCTAACAGACTGCTTTCCAAAGATTCTTGTAAATATTCTTCCTTATTTTGCCTAT        3900
 S  L  L  T  D  C  F  P  K  I  L  V  N  I  L  P  Y  F  A  Y          1300

          .         .         .         .         .         .
 GAGGGTACCAGAGACAGTGGGATGGCACAGCAAAGAGAGACTGCTACCAAGGTCTATGAT        3960
 E  G  T  R  D  S  G  M  A  Q  Q  R  E  T  A  T  K  V  Y  D          1320

          .         .         .    | 29    .         .         .
 ATGCTTAAAAGTGAAAACTTATTGGGAAAACAG | ATTGATCACTTATTCATTAGTAATTTA     4020
 M  L  K  S  E  N  L  L  G  K  Q   | I  D  H  L  F  I  S  N  L       1340

          .         .         .         .         .         .
 CCAGAGATTGTGGTGGAGTTATTGATGACGTTACATGAGCCAGCAAATTCTAGTGCCAGT        4080
 P  E  I  V  V  E  L  L  M  T  L  H  E  P  A  N  S  S  A  S          1360

          .         .          | 30        .         .         .
 CAGAGCACTGACCTCTGTGACTTTTCAGG | GGATTTGGATCCTGCTCCTAATCCACCTCAT     4140
 Q  S  T  D  L  C  D  F  S  G  |  D  L  D  P  A  P  N  P  P  H       1380

          .         .         .         .         .         .
 TTTCCATCGCATGTGATTAAAGCAACATTTGCCTATATCAGCAATTGTCATAAAACCAAG        4200
 F  P  S  H  V  I  K  A  T  F  A  Y  I  S  N  C  H  K  T  K          1400

          .         .         .       | 31 .         .         .
 TTAAAAAGCATTTTAGAAATTCTTTCCAAAAGCCCT | GATTCCTATCAGAAAATTCTTCTT     4260
 L  K  S  I  L  E  I  L  S  K  S  P   | D  S  Y  Q  K  I  L  L       1420

          .         .         .         .         .         .
 GCCATATGTGAGCAAGCAGCTGAAACAAATAATGTTTATAAGAAGCACAGAATTCTTAAA        4320
 A  I  C  E  Q  A  A  E  T  N  N  V  Y  K  K  H  R  I  L  K          1440

          .         .         .         .         .         .
 ATATATCACCTGTTTGTTAGTTTATTACTGAAAGATATAAAAAGTGGCTTAGGAGGAGCT        4380
 I  Y  H  L  F  V  S  L  L  L  K  D  I  K  S  G  L  G  G  A          1460

          .         .         .         .         .       | 32 .
 TGGGCCTTTGTTCTTCGAGACGTTATTTATACTTTGATTCACTATATCAACCAAAG | GCCT     4440
 W  A  F  V  L  R  D  V  I  Y  T  L  I  H  Y  I  N  Q  R  |  P       1480

          .         .         .         .         .         .
 TCTTGTATCATGGATGTGTCATTACGTAGCTTCTCCCTTTGTTGTGACTTATTAAGTCAG        4500
 S  C  I  M  D  V  S  L  R  S  F  S  L  C  C  D  L  L  S  Q          1500

          .         .         .         .         .         .
 GTTTGCCAGACAGCCGTGACTTACTGTAAGGATGCTCTAGAAAACCATCTTCATGTTATT        4560
 V  C  Q  T  A  V  T  Y  C  K  D  A  L  E  N  H  L  H  V  I          1520

          .         .         .         .         .  | 33      .
 GTTGGTACACTTATACCCCTTGTGTATGAGCAGGTGGAGGTTCAGAAACAG | GTATTGGAC     4620
 V  G  T  L  I  P  L  V  Y  E  Q  V  E  V  Q  K  Q   | V  L  D       1540

          .         .         .         .         .         .
 TTGTTGAAATACTTAGTGATAGATAACAAGGATAATGAAAACCTCTATATCACGATTAAG        4680
 L  L  K  Y  L  V  I  D  N  K  D  N  E  N  L  Y  I  T  I  K          1560

          .         .         .         .         .         .
 CTTTTAGATCCTTTTCCTGACCATGTTGTTTTTAAGGATTTGCGTATTACTCAGCAAAAA        4740
 L  L  D  P  F  P  D  H  V  V  F  K  D  L  R  I  T  Q  Q  K          1580

          .         .         .       | 34 .         .         .
 ATCAAATACAGTAGAGGACCCTTTTCACTCTTGGAG | GAAATTAACCATTTTCTCTCAGTA     4800
 I  K  Y  S  R  G  P  F  S  L  L  E   | E  I  N  H  F  L  S  V       1600

          .         .         .         .         .         .
 AGTGTTTATGATGCACTTCCATTGACAAGACTTGAAGGACTAAAGGATCTTCGAAGACAA        4860
 S  V  Y  D  A  L  P  L  T  R  L  E  G  L  K  D  L  R  R  Q          1620

          .         .         .         .          | 35        .
 CTGGAACTACATAAAGATCAGATGGTGGACATTATGAGAGCTTCTCAGG | ATAATCCGCAA     4920
 L  E  L  H  K  D  Q  M  V  D  I  M  R  A  S  Q  D |   N  P  Q       1640

          .         .         .         .         .         .
 GATGGGATTATGGTGAAACTAGTTGTCAATTTGTTGCAGTTATCCAAGATGGCAATAAAC        4980
 D  G  I  M  V  K  L  V  V  N  L  L  Q  L  S  K  M  A  I  N          1660

          .         .      | 36  .         .         .         .
 CACACTGGTGAAAAAGAAGTTCTAG | AGGCTGTTGGAAGCTGCTTGGGAGAAGTGGGTCCT     5040
 H  T  G  E  K  E  V  L  E |   A  V  G  S  C  L  G  E  V  G  P       1680

          .         .         .         .         .         .
 ATAGATTTCTCTACCATAGCTATACAACATAGTAAAGATGCATCTTATACCAAGGCCCTT        5100
 I  D  F  S  T  I  A  I  Q  H  S  K  D  A  S  Y  T  K  A  L          1700

          .         .         .         .         .         .
 AAGTTATTTGAAGATAAAGAACTTCAGTGGACCTTCATAATGCTGACCTACCTGAATAAC        5160
 K  L  F  E  D  K  E  L  Q  W  T  F  I  M  L  T  Y  L  N  N          1720

          .        | 37.         .         .         .         .
 ACACTGGTAGAAGATTG | TGTCAAAGTTCGATCAGCAGCTGTTACCTGTTTGAAAAACATT     5220
 T  L  V  E  D  C  |  V  K  V  R  S  A  A  V  T  C  L  K  N  I       1740

          .         .         .         .         .         .
 TTAGCCACAAAGACTGGACATAGTTTCTGGGAGATTTATAAGATGACAACAGATCCAATG        5280
 L  A  T  K  T  G  H  S  F  W  E  I  Y  K  M  T  T  D  P  M          1760

          .         .         .          | 38        .         .
 CTGGCCTATCTACAGCCTTTTAGAACATCAAGAAAAAAG | TTTTTAGAAGTACCCAGATTT     5340
 L  A  Y  L  Q  P  F  R  T  S  R  K  K   | F  L  E  V  P  R  F       1780

          .         .         .         .         .         .
 GACAAAGAAAACCCTTTTGAAGGCCTGGATGATATAAATCTGTGGATTCCTCTAAGTGAA        5400
 D  K  E  N  P  F  E  G  L  D  D  I  N  L  W  I  P  L  S  E          1800

          .         .         .         .         .         .
 AATCATGACATTTGGATAAAGACACTGACTTGTGCTTTTTTGGACAGTGGAGGCACAAAA        5460
 N  H  D  I  W  I  K  T  L  T  C  A  F  L  D  S  G  G  T  K          1820

          .         .         .       | 39 .         .         .
 TGTGAAATTCTTCAATTATTAAAGCCAATGTGTGAA | GTGAAAACTGACTTTTGTCAGACT     5520
 C  E  I  L  Q  L  L  K  P  M  C  E   | V  K  T  D  F  C  Q  T       1840

          .         .         .         .         .         .
 GTACTTCCATACTTGATTCATGATATTTTACTCCAAGATACAAATGAATCATGGAGAAAT        5580
 V  L  P  Y  L  I  H  D  I  L  L  Q  D  T  N  E  S  W  R  N          1860

          .         .         .         .         .         .
 CTGCTTTCTACACATGTTCAGGGATTTTTCACCAGCTGTCTTCGACACTTCTCGCAAACG        5640
 L  L  S  T  H  V  Q  G  F  F  T  S  C  L  R  H  F  S  Q  T          1880

          .         .         .     | 40   .         .         .
 AGCCGATCCACAACCCCTGCAAACTTGGATTCAG | AGTCAGAGCACTTTTTCCGATGCTGT     5700
 S  R  S  T  T  P  A  N  L  D  S  E |   S  E  H  F  F  R  C  C       1900

          .         .         .         .         .         .
 TTGGATAAAAAATCACAAAGAACAATGCTTGCTGTTGTGGACTACATGAGAAGACAAAAG        5760
 L  D  K  K  S  Q  R  T  M  L  A  V  V  D  Y  M  R  R  Q  K          1920

    | 41     .         .         .         .         .         .
 AG | ACCTTCTTCAGGAACAATTTTTAATGATGCTTTCTGGCTGGATTTAAATTATCTAGAA     5820
 R  |  P  S  S  G  T  I  F  N  D  A  F  W  L  D  L  N  Y  L  E       1940

          .         .         .         .         .         .
 GTTGCCAAGGTAGCTCAGTCTTGTGCTGCTCACTTTACAGCTTTACTCTATGCAGAAATC        5880
 V  A  K  V  A  Q  S  C  A  A  H  F  T  A  L  L  Y  A  E  I          1960

          .         .         .         | 42         .         .
 TATGCAGATAAGAAAAGTATGGATGATCAAGAGAAAAG | AAGTCTTGCATTTGAAGAAGGA     5940
 Y  A  D  K  K  S  M  D  D  Q  E  K  R  |  S  L  A  F  E  E  G       1980

          .         .         .         .         .         .
 AGCCAGAGTACAACTATTTCTAGCTTGAGTGAAAAAAGTAAAGAAGAAACTGGAATAAGT        6000
 S  Q  S  T  T  I  S  S  L  S  E  K  S  K  E  E  T  G  I  S          2000

        | 43 .         .         .         .         .         .
 TTACAG | GATCTTCTCTTAGAAATCTACAGAAGTATAGGGGAGCCAGATAGTTTGTATGGC     6060
 L  Q   | D  L  L  L  E  I  Y  R  S  I  G  E  P  D  S  L  Y  G       2020

          .         .         .      | 44  .         .         .
 TGTGGTGGAGGGAAGATGTTACAACCCATTACTAG | ACTACGAACATATGAACACGAAGCA     6120
 C  G  G  G  K  M  L  Q  P  I  T  R  |  L  R  T  Y  E  H  E  A       2040

          .         .         .         .         .         .
 ATGTGGGGCAAAGCCCTAGTAACATATGACCTCGAAACAGCAATCCCCTCATCAACACGC        6180
 M  W  G  K  A  L  V  T  Y  D  L  E  T  A  I  P  S  S  T  R          2060

          .         | 45         .         .         .         .
 CAGGCAGGAATCATTCAG | GCCTTGCAGAATTTGGGACTCTGCCATATTCTTTCCGTCTAT     6240
 Q  A  G  I  I  Q   | A  L  Q  N  L  G  L  C  H  I  L  S  V  Y       2080

          .         .         .         .         .         .
 TTAAAAGGATTGGATTATGAAAATAAAGACTGGTGTCCTGAACTAGAAGAACTTCATTAC        6300
 L  K  G  L  D  Y  E  N  K  D  W  C  P  E  L  E  E  L  H  Y          2100

          .         .         .         .        | 46.         .
 CAAGCAGCATGGAGGAATATGCAGTGGGACCATTGCACTTCCGTCAG | CAAAGAAGTAGAA     6360
 Q  A  A  W  R  N  M  Q  W  D  H  C  T  S  V  S  |  K  E  V  E       2120

          .         .         .         .         .         .
 GGAACCAGTTACCATGAATCATTGTACAATGCTCTACAATCTCTAAGAGACAGAGAATTC        6420
 G  T  S  Y  H  E  S  L  Y  N  A  L  Q  S  L  R  D  R  E  F          2140

          .         .         .   | 47     .         .         .
 TCTACATTTTATGAAAGTCTCAAATATGCCAG | AGTAAAAGAAGTGGAAGAGATGTGTAAG     6480
 S  T  F  Y  E  S  L  K  Y  A  R  |  V  K  E  V  E  E  M  C  K       2160

          .         .         .         .         .         .
 CGCAGCCTTGAGTCTGTGTATTCGCTCTATCCCACACTTAGCAGGTTGCAGGCCATTGGA        6540
 R  S  L  E  S  V  Y  S  L  Y  P  T  L  S  R  L  Q  A  I  G          2180

          .         .         .   | 48     .         .         .
 GAGCTGGAAAGCATTGGGGAGCTTTTCTCAAG | ATCAGTCACACATAGACAACTCTCTGAA     6600
 E  L  E  S  I  G  E  L  F  S  R  |  S  V  T  H  R  Q  L  S  E       2200

          .         .         .         .         .         .
 GTATATATTAAGTGGCAGAAACACTCCCAGCTTCTCAAGGACAGTGATTTTAGTTTTCAG        6660
 V  Y  I  K  W  Q  K  H  S  Q  L  L  K  D  S  D  F  S  F  Q          2220

          .         .         .         .         .         .
 GAGCCTATCATGGCTCTACGCACAGTCATTTTGGAGATCCTGATGGAAAAGGAAATGGAC        6720
 E  P  I  M  A  L  R  T  V  I  L  E  I  L  M  E  K  E  M  D          2240

          .         .         .         .         .         .
 AACTCACAAAGAGAATGTATTAAGGACATTCTCACCAAACACCTTGTAGAACTCTCTATA        6780
 N  S  Q  R  E  C  I  K  D  I  L  T  K  H  L  V  E  L  S  I          2260

          .         .        | 49.         .         .         .
 CTGGCCAGAACTTTCAAGAACACTCAG | CTCCCTGAAAGGGCAATATTTCAAATTAAACAG     6840
 L  A  R  T  F  K  N  T  Q   | L  P  E  R  A  I  F  Q  I  K  Q       2280

          .         .         .         .         .         .
 TACAATTCAGTTAGCTGTGGAGTCTCTGAGTGGCAGCTGGAAGAAGCACAAGTATTCTGG        6900
 Y  N  S  V  S  C  G  V  S  E  W  Q  L  E  E  A  Q  V  F  W          2300

          .         .         .         .         .         .
 GCAAAAAAGGAGCAGAGTCTTGCCCTGAGTATTCTCAAGCAAATGATCAAGAAGTTGGAT        6960
 A  K  K  E  Q  S  L  A  L  S  I  L  K  Q  M  I  K  K  L  D          2320

          .      | 50  .         .         .         .         .
 GCCAGCTGTGCAGCG | AACAATCCCAGCCTAAAACTTACATACACAGAATGTCTGAGGGTT     7020
 A  S  C  A  A   | N  N  P  S  L  K  L  T  Y  T  E  C  L  R  V       2340

          .         .         .         .         .         .
 TGTGGCAACTGGTTAGCAGAAACGTGCTTAGAAAATCCTGCGGTCATCATGCAGACCTAT        7080
 C  G  N  W  L  A  E  T  C  L  E  N  P  A  V  I  M  Q  T  Y          2360

           | 51        .         .         .         .         .
 CTAGAAAAG | GCAGTAGAAGTTGCTGGAAATTATGATGGAGAAAGTAGTGATGAGCTAAGA     7140
 L  E  K   | A  V  E  V  A  G  N  Y  D  G  E  S  S  D  E  L  R       2380

          .         .         .         .         .         .
 AATGGAAAAATGAAGGCATTTCTCTCATTAGCCCGGTTTTCAGATACTCAATACCAAAGA        7200
 N  G  K  M  K  A  F  L  S  L  A  R  F  S  D  T  Q  Y  Q  R          2400

          .         .         .         .         .         .
 ATTGAAAACTACATGAAATCATCGGAATTTGAAAACAAGCAAGCTCTCCTGAAAAGAGCC        7260
 I  E  N  Y  M  K  S  S  E  F  E  N  K  Q  A  L  L  K  R  A          2420

          .         .         .         .        | 52.         .
 AAAGAGGAAGTAGGTCTCCTTAGGGAACATAAAATTCAGACAAACAG | ATACACAGTAAAG     7320
 K  E  E  V  G  L  L  R  E  H  K  I  Q  T  N  R  |  Y  T  V  K       2440

          .         .         .         .         .         .
 GTTCAGCGAGAGCTGGAGTTGGATGAATTAGCCCTGCGTGCACTGAAAGAGGATCGTAAA        7380
 V  Q  R  E  L  E  L  D  E  L  A  L  R  A  L  K  E  D  R  K          2460

          .         .         .         .         .         .
 CGCTTCTTATGTAAAGCAGTTGAAAATTATATCAACTGCTTATTAAGTGGAGAAGAACAT        7440
 R  F  L  C  K  A  V  E  N  Y  I  N  C  L  L  S  G  E  E  H          2480

          .         .         .         .         .         .
 GATATGTGGGTATTCCGACTTTGTTCCCTCTGGCTTGAAAATTCTGGAGTTTCTGAAGTC        7500
 D  M  W  V  F  R  L  C  S  L  W  L  E  N  S  G  V  S  E  V          2500

          .      | 53  .         .         .         .         .
 AATGGCATGATGAAG | AGAGACGGAATGAAGATTCCAACATATAAATTTTTGCCTCTTATG     7560
 N  G  M  M  K   | R  D  G  M  K  I  P  T  Y  K  F  L  P  L  M       2520

          .         .         .         .         .         .
 TACCAATTGGCTGCTAGAATGGGGACCAAGATGATGGGAGGCCTAGGATTTCATGAAGTC        7620
 Y  Q  L  A  A  R  M  G  T  K  M  M  G  G  L  G  F  H  E  V          2540

           | 54        .         .         .         .         .
 CTCAATAAT | CTAATCTCTAGAATTTCAATGGATCACCCCCATCACACTTTGTTTATTATA     7680
 L  N  N   | L  I  S  R  I  S  M  D  H  P  H  H  T  L  F  I  I       2560

          .         .         .         .         .         .
 CTGGCCTTAGCAAATGCAAACAGAGATGAATTTCTGACTAAACCAGAGGTAGCCAGAAGA        7740
 L  A  L  A  N  A  N  R  D  E  F  L  T  K  P  E  V  A  R  R          2580

          .         .         .         .         | 55         .
 AGCAGAATAACTAAAAATGTGCCTAAACAAAGCTCTCAGCTTGATGAG | GATCGAACAGAG     7800
 S  R  I  T  K  N  V  P  K  Q  S  S  Q  L  D  E   | D  R  T  E       2600

          .         .         .         .         .         .
 GCTGCAAATAGAATAATATGTACTATCAGAAGTAGGAGACCTCAGATGGTCAGAAGTGTT        7860
 A  A  N  R  I  I  C  T  I  R  S  R  R  P  Q  M  V  R  S  V          2620

          .         .         .         .         .         .
 GAGGCACTTTGTGATGCTTATATTATATTAGCAAACTTAGATGCCACTCAGTGGAAGACT        7920
 E  A  L  C  D  A  Y  I  I  L  A  N  L  D  A  T  Q  W  K  T          2640

         | 56.         .         .         .         .         .
 CAGAGAA | AAGGCATAAATATTCCAGCAGACCAGCCAATTACTAAACTTAAGAATTTAGAA     7980
 Q  R  K |   G  I  N  I  P  A  D  Q  P  I  T  K  L  K  N  L  E       2660

          .         .         . | 57       .         .         .
 GATGTTGTTGTCCCTACTATGGAAATTAAG | GTGGACCACACAGGAGAATATGGAAATCTG     8040
 D  V  V  V  P  T  M  E  I  K   | V  D  H  T  G  E  Y  G  N  L       2680

          .         .         .         .         .         .
 GTGACTATACAGTCATTTAAAGCAGAATTTCGCTTAGCAGGAGGTGTAAATTTACCAAAA        8100
 V  T  I  Q  S  F  K  A  E  F  R  L  A  G  G  V  N  L  P  K          2700

          .         .         .         .         .  | 58      .
 ATAATAGATTGTGTAGGTTCCGATGGCAAGGAGAGGAGACAGCTTGTTAAG | GGCCGTGAT     8160
 I  I  D  C  V  G  S  D  G  K  E  R  R  Q  L  V  K   | G  R  D       2720

          .         .         .         .         .         .
 GACCTGAGACAAGATGCTGTCATGCAACAGGTCTTCCAGATGTGTAATACATTACTGCAG        8220
 D  L  R  Q  D  A  V  M  Q  Q  V  F  Q  M  C  N  T  L  L  Q          2740

          .         .         .         .         | 59         .
 AGAAACACGGAAACTAGGAAGAGGAAATTAACTATCTGTACTTATAAG | GTGGTTCCCCTC     8280
 R  N  T  E  T  R  K  R  K  L  T  I  C  T  Y  K   | V  V  P  L       2760

          .         .         .         .         .         .
 TCTCAGCGAAGTGGTGTTCTTGAATGGTGCACAGGAACTGTCCCCATTGGTGAATTTCTT        8340
 S  Q  R  S  G  V  L  E  W  C  T  G  T  V  P  I  G  E  F  L          2780

          .         .         .         .         .         .
 GTTAACAATGAAGATGGTGCTCATAAAAGATACAGGCCAAATGATTTCAGTGCCTTTCAG        8400
 V  N  N  E  D  G  A  H  K  R  Y  R  P  N  D  F  S  A  F  Q          2800

          .         | 60         .         .         .         .
 TGCCAAAAGAAAATGATG | GAGGTGCAAAAAAAGTCTTTTGAAGAGAAATATGAAGTCTTC     8460
 C  Q  K  K  M  M   | E  V  Q  K  K  S  F  E  E  K  Y  E  V  F       2820

          .         .         .         .         .         .
 ATGGATGTTTGCCAAAATTTTCAACCAGTTTTCCGTTACTTCTGCATGGAAAAATTCTTG        8520
 M  D  V  C  Q  N  F  Q  P  V  F  R  Y  F  C  M  E  K  F  L          2840

          .         .         .         .         .         .
 GATCCAGCTATTTGGTTTGAGAAGCGATTGGCTTATACGCGCAGTGTAGCTACTTCTTCT        8580
 D  P  A  I  W  F  E  K  R  L  A  Y  T  R  S  V  A  T  S  S          2860

      | 61   .         .         .         .         .         .
 ATTG | TTGGTTACATACTTGGACTTGGTGATAGACATGTACAGAATATCTTGATAAATGAG     8640
 I  V |   G  Y  I  L  G  L  G  D  R  H  V  Q  N  I  L  I  N  E       2880

          .         .         .  | 62      .         .         .
 CAGTCAGCAGAACTTGTACATATAGATCTAG | GTGTTGCTTTTGAACAGGGCAAAATCCTT     8700
 Q  S  A  E  L  V  H  I  D  L  G |   V  A  F  E  Q  G  K  I  L       2900

          .         .         .         .         .         .
 CCTACTCCTGAGACAGTTCCTTTTAGACTCACCAGAGATATTGTGGATGGCATGGGCATT        8760
 P  T  P  E  T  V  P  F  R  L  T  R  D  I  V  D  G  M  G  I          2920

          .         .       | 63 .         .         .         .
 ACGGGTGTTGAAGGTGTCTTCAGAAG | ATGCTGTGAGAAAACCATGGAAGTGATGAGAAAC     8820
 T  G  V  E  G  V  F  R  R  |  C  C  E  K  T  M  E  V  M  R  N       2940

          .         .         . | 64       .         .         .
 TCTCAGGAAACTCTGTTAACCATTGTAGAG | GTCCTTCTATATGATCCACTCTTTGACTGG     8880
 S  Q  E  T  L  L  T  I  V  E   | V  L  L  Y  D  P  L  F  D  W       2960

          .         .         .         .         .         .
 ACCATGAATCCTTTGAAAGCTTTGTATTTACAGCAGAGGCCGGAAGATGAAACTGAGCTT        8940
 T  M  N  P  L  K  A  L  Y  L  Q  Q  R  P  E  D  E  T  E  L          2980

          .         .         .         .        | 65.         .
 CACCCTACTCTGAATGCAGATGACCAAGAATGCAAACGAAATCTCAG | TGATATTGACCAG     9000
 H  P  T  L  N  A  D  D  Q  E  C  K  R  N  L  S  |  D  I  D  Q       3000

          .         .         .         .         .         .
 AGTTTCAACAAAGTAGCTGAACGTGTCTTAATGAGACTACAAGAGAAACTGAAAGGAGTG        9060
 S  F  N  K  V  A  E  R  V  L  M  R  L  Q  E  K  L  K  G  V          3020

          .         .         .         .         .         .
 GAAGAAGGCACTGTGCTCAGTGTTGGTGGACAAGTGAATTTGCTCATACAGCAGGCCATA        9120
 E  E  G  T  V  L  S  V  G  G  Q  V  N  L  L  I  Q  Q  A  I          3040

          .         .         .         .         . 
 GACCCCAAAAATCTCAGCCGACTTTTCCCAGGATGGAAAGCTTGGGTGTGA                 9171
 D  P  K  N  L  S  R  L  F  P  G  W  K  A  W  V  X                   3056

          .         .         .         .         .         .
 tcttcagtatatgaattaccctttcattcagcctttagaaattatattttagcctttatt        *60

          .         .         .         .         .         .
 tttaacctgccaacatactttaagtagggattaatatttaagtgaactattgtgggtttt        *120

          .         .         .         .         .         .
 tttgaatgttggttttaatacttgatttaatcaccactcaaaaatgttttgatggtctta        *180

          .         .         .         .         .         .
 aggaacatctctgctttcactctttagaaataatggtcattcgggctgggcgcagcggct        *240

          .         .         .         .         .         .
 cacgcctgtaatcccagcactttgggaggccgaggtgagcggatcacaaggtcaggagtt        *300

          .         .         .         .         .         .
 cgagaccagcctggccaagagaccagcctggccagtatggtgaaaccctgtctctactaa        *360

          .         .         .         .         .         .
 aaatacaaaaattagccgagcatggtggcgggcacctgtaatcccagctactcgagaggc        *420

          .         .         .         .         .         .
 tgaggcaggagaatctcttgaacctgggaggtgaaggttgctgtgggccaaaatcatgcc        *480

          .         .         .         .         .         .
 attgcactccagcctgggtgacaagagcgaaactccatctcaaaaaaaaaaaaaaaaaac        *540

          .         .         .         .         .         .
 agaaacttatttggatttttcctagtaagatcactcagtgttactaaataatgaagttgt        *600

          .         .         .         .         .         .
 tatggagaacaaatttcaaagacacagttagtgtagttactatttttttaagtgtgtatt        *660

          .         .         .         .         .         .
 aaaacttctcattctattctctttatcttttaagcccttctgtactgtccatgtatgtta        *720

          .         .         .         .         .         .
 tctttctgtgataacttcatagattgccttctagttcatgaattctcttgtcagatgtat        *780

          .         .         .         .         .         .
 ataatctcttttaccctatccattgggcttcttctttcagaaattgtttttcatttctaa        *840

          .         .         .         .         .         .
 ttatgcatcatttttcagatctctgtttcttgatgtcatttttaatgtttttttaatgtt        *900

          .         .         .         .         .         .
 ttttatgtcactaattattttaaatgtctgtacttgatagacactgtaatagttctatta        *960

          .         .         .         .         .         .
 aatttagttcctgctgtttatatctgttgatttttgtatttgataggctgttcatccagt        *1020

          .         .         .         .         .         .
 tttgtctttttgaaaagtgagtttattttcagcaaggctttatctatgggaatcttgagt        *1080

          .         .         .         .         .         .
 gtctgtttatgtcatattcccagggctgttgctgcacacaagcccattcttattttaatt        *1140

          .         .         .         .         .         .
 tcttggctttagggtttccatacctgaagtgtagcataaatactgataggagatttccca        *1200

          .         .         .         .         .         .
 ggccaaggcaaacacacttcctcctcatctccttgtgctagtgggcagaatatttgattg        *1260

          .         .         .         .         .         .
 atgcctttttcactgagagtataagcttccatgtgtcccacctttatggcaggggtggaa        *1320

          .         .         .         .         .         .
 ggaggtacatttaattcccactgcctgcctttggcaagccctgggttctttgctccccat        *1380

          .         .         .         .         .         .
 atagatgtctaagctaaaagccgtgggttaatgagactggcaaattgttccaggacagct        *1440

          .         .         .         .         .         .
 acagcatcagctcacatattcacctctctggtttttcattcccctcatttttttctgaga        *1500

          .         .         .         .         .         .
 cagagtcttgctctgtcacccaggctggagtgcagtggcatgatctcagctcactgaaac        *1560

          .         .         .         .         .         .
 ctctgcctcctgggttcaagcaattctcctgcctcagcctcctgagtagctgggactaca        *1620

          .         .         .         .         .         .
 ggcgtgtgccaacacgcccggctaattttttgtatttttattagagacggagtttcaccg        *1680

          .         .         .         .         .         .
 tgttagccaggatggtctcgatcgcttgacctcgtgatccaccctcctcggcctcccaaa        *1740

          .         .         .         .         .         .
 gtgctgggattacaggtgtgagccaccgcgcccggcctcattcccctcatttttgaccgt        *1800

          .         .         .         .         .         .
 aaggatttcccctttcttgtaagttctgctatgtatttaaaagaatgttttctacatttt        *1860

          .         .         .         .         .         .
 atccagcatttctctgtgttctgttggaagggaagggcttaggtatctagtttgatacat        *1920

          .         .         .         .         .         .
 aggtagaagtggaacatttctctgtcccccagctgtcatcatataagataaacatcagat        *1980

          .         .         .         .         .         .
 aaaaagccacctgaaagtaaaactactgactcgtgtattagtgagtataatctcttctcc        *2040

          .         .         .         .         .         .
 atccttaggaaaatgttcatcccagctgcggagattaacaaatgggtgattgagctttct        *2100

          .         .         .         .         .         .
 cctcgtatttggaccttgaaggttatataaatttttttcttatgaagagttggcatttct        *2160

          .         .         .         .         .         .
 ttttattgccaatggcaggcactcattcatatttgatctcctcaccttcccctcccctaa        *2220

          .         .         .         .         .         .
 aaccaatctccagaactttttggactataaatttcttggtttgacttctggagaactgtt        *2280

          .         .         .         .         .         .
 cagaatattactttgcatttcaaattacaaacttaccttggtgtatctttttcttacaag        *2340

          .         .         .         .         .         .
 ctgcctaaatgaatatttggtatatattggtagttttattactatagtaaatcaaggaaa        *2400

          .         .         .         .         .         .
 tgcagtaaacttaaaatgtctttaagaaagccctgaaatcttcatgggtgaaattagaaa        *2460

          .         .         .         .         .         .
 ttatcaactagataatagtatagataaatgaatttgtagctaattcttgctagttgttgc        *2520

          .         .         .         .         .         .
 atccagagagctttgaataacatcattaatctactctttagccttgcatggtatgctatg        *2580

          .         .         .         .         .         .
 aggctcctgttctgttcaagtattctaatcaatggctttgaaaagtttatcaaatttaca        *2640

          .         .         .         .         .         .
 tacagatcacaagcctaggagaaataactaattcacagatgacagaattaagattataaa        *2700

          .         .         .         .         .         .
 agattttttttttgtaattttagtagagacagggttgccattgtattccagccttggcga        *2760

          .         .         .         .         .         .
 cagagcaagactctgcctcaaaaaaaaaaaaaaaaaggttttggcaagctggaactcttt        *2820

          .         .         .         .         .         .
 ctgcaaatgactaagatagaaaactgccaaggacaaatgaggagtagttagattttgaaa        *2880

          .         .         .         .         .         .
 atattaatcatagaatagttgttgtatgctaagtcactgacccatattatgtacagcatt        *2940

          .         .         .         .         .         .
 tctgatctttactttgcaagattagtgatactatcccaatacactgctggagaaatcaga        *3000

          .         .         .         .         .         .
 atttggagaaataagttgtccaaggcaagaagatagtaaattataagtacaagtgtaata        *3060

          .         .         .         .         .         .
 tggacagtatctaacttgaaaagatttcaggcgaaaagaatctggggtttgccagtcagt        *3120

          .         .         .         .         .         .
 tgctcaaaaggtcaatgaaaaccaaatagtgaagctatcagagaagctaataaattatag        *3180

          .         .         .         .         .         .
 actgcttgaacagttgtgtccagattaagggagataatagctttcccaccctactttgtg        *3240

          .         .         .         .         .         .
 caggtcatacctccccaaagtgtttacctaatcagtaggttcacaaactcttggtcatta        *3300

          .         .         .         .         .         .
 tagtatatgcctaaaatgtatgcacttaggaatgctaaaaatttaaatatggtctaaagc        *3360

          .         .         .         .         .         .
 aaataaaagcaaagaggaaaaactttggacatcgtaaagactagaatagtcttttaaaaa        *3420

          .         .         .         .         .         .
 gaaagccagtatattggtttgaaatatagagatgtgtcccaatttcaagtattttaattg        *3480

          .         .         .         .         .         .
 caccttaatgaaattatctattttctatagattttagtactattgaatgtattactttac        *3540

          .         .         .         .         . 
 tgttacctgaatttattataaagtgtttttgaataaataattctaaaagca                 *3591

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Ataxia Telangiectasia Mutated protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift mutations, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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